A Bet's A Bet tells the story of Vince, New England's most successful divorce attorney. To Vince, life is one big competition, and losing is unacceptable. This also applies in his dating life with his love 'em and leave 'em approach. Then Vince meets Jane, who is beautiful, successful and also extremely driven. Together they enter into a series of entertaining wagers with each other where the winner gets to decide the fate of the loser. After all, "A Bet's a Bet!"

A consumer affair rep who works from her apartment decides to play hooky one day, and spends her time calling random people, looking for new connections.

A self-absorbed writer, stuck in more ways than one, rediscovers himself, his offbeat family, and what it means to be happy when he meets Joy, a spirited young woman who asks him to write her obituary.

Melinda loves her fiancé Ron. Her brother Todd, doesn't approve of his upcoming brother-in-law. He wants Melinda to cancel the wedding, but for her to do that, he must get Ron to mess up. He hopes to achieve his plan by organizing the world's wildest bachelor party.

A young woman discovers a Christmas-themed dreamworld inside a magical snowglobe.

In Los Angeles, the police put a residential building in quarantine. Meanwhile, the flight attendants of Trans Sky Air, Jenny and Paula, are welcoming the passengers of flight TS Air 318 from Los Angeles to Kansas City with Captain Forrest and Co-Pilot Wilsy. Teacher Henry brings a cage of hamsters to the cabin, but Jenny tells him that it should be transported in the cargo hold. However, one hamster bites the fingertip of the fat passenger Ralph. Soon, Ralph vomits and becomes aggressive, attacking Paula. The male passengers help Jenny and lock Ralph in the bathroom while Captain Forrest requests an emergency landing. When they land in the airport, they find all the gates closed and the Captain heads the plane to an abandoned terminal. Employee Ed helps the crew and passengers to reach the exit, but they find that they are closed. Soon they discover that the place is in quarantine and there is no way out.

Will, an escaped convict, inadvertently takes refuge in a barn the same night the owners, April and Martin, get into a terrible fight. A gun shot goes off inside the house. April drags Martin's body outside and discovers Will. He convinces her that he is not there to harm her but has witnessed the murder so they must cooperate or both go to prison. The two take out to dispose of the body only to find out he is not dead. The task of disposal turns into a kidnapping nightmare and, as the two try to navigate the turn of events, they find they must make some hard choices to keep from losing it all.